FWIW, Hendrix played lefty, right side up. Doyle Bramhall II, Rusty Burns, and Shake Russell play lefty upside down.
I had to look at pictures just to verify that. I then took one of my guitars and restrung it upside down and redid the bridge (tunematic) I then drank heavily cried and screamed to the sky... it is a totally different sound because 1st of all the miking on the pickups are reversed and once you get as an example playing a D upside down comfortable it gives you a totally different sound.